Nicknamed "the Moor" for his dark complexion, Alessandro was most likely the illegitimate son of Giulio de' Medici, born to a servant of African descent. As Pope Clement VII, Giulio selected Alessandro as the Duke of Florence. Alessandro ruled from 1532 until his assassination by a distant cousin in 1537. Although initially admired by his subjects, Alessandro became regarded as a corrupt figure due to his misuse of taxes and attempts to extend his power.

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