A native of the Suffolk town of Bury St Edmunds, she married Thomas Clarkson in 1796. She shared his radicalism and became close friends with the Wordsworths, Southey, Coleridge and Crabb Robinson. Owing to her illness, she was treated by Beddoes in Bristol in 1804 and 1805; she and her husband moved south to Suffolk from the Lake District for the sake of her health in 1806.